Πλοήγηση ανά Συγγραφέα "Kanavaros, P."
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Association of allelic loss at the FHIT locus and p53 alterations with tumour kinetics and chromosomal instability in non-small cell lung carcinomas (NSCLCs)
Garinis, G. A.; Gorgoulis, V. G.; Mariatos, G.; Zacharatos, P.; Kotsinas, A.; Liloglou, T.; Foukas, P.; Kanavaros, P.; Kastrinakis, N. G.; Vassilakopoulos, T.; Vogiatzi, T.; Field, J. K.; Kittas, C. (2001)The FHIT gene, located at the FRA3B fragile site of chromosome 3p14.2, encodes a 16.8 kD homologue of the yeast enzyme diadenosine tetraphosphate (Ap(4)A) hydrolase, Frequent allelic losses at this region in various ... -
Changing pattern of cytokeratin 7 and 20 expression from normal epithelium to intestinal metaplasia of the gastric mucosa and gastroesophageal junction
Jovanovic, I.; Tzardi, M.; Mouzas, I. A.; Micev, M.; Pesko, P.; Milosavijevic, T.; Zois, M.; Sganzos, M.; Delides, G.; Kanavaros, P. (2002)It is currently unclear whether intestinal metaplasia at the esophagogastric junction and in the distal esophagus represent a continuum of the same underlying disease process, i.e., gastroesophageal reflux, or constitute ... -
Cytokine effects on cell survival and death of A549 lung carcinoma cells
Kastamoulas, M.; Chondrogiannis, G.; Kanavaros, P.; Vartholomatos, G.; Bai, M.; Briasoulis, E.; Arvanitis, D.; Galani, V. (2013)Purpose: IL-13, TNF-alpha and IL-1 beta have various effects on lung cancer growth and death, but the signaling pathways mediating these effects have not been extensively analyzed. Therefore, the effects of IL-13, TNF-alpha ... -
Cytokine Effects on Cell Viability and Death of Prostate Carcinoma Cells
Chondrogiannis, G.; Kastamoulas, M.; Kanavaros, P.; Vartholomatos, G.; Bai, M.; Baltogiannis, D.; Sofikitis, N.; Arvanitis, D.; Galani, V. (2014)We analyzed the effects of IL-13, IFN-gamma, and IL-1 beta on cell viability and death of LNCaP and PC-3 cells and major signaling pathways involved in these effects. Significant increase of LNCaP cell death (apoptotic and ... -
Expression of cytotoxic proteins in peripheral T-cell and natural killer-cell (NK) lymphomas: Association with extranodal site, NK or Tγδ phenotype, anaplastic morphology and CD30 expression
Kanavaros, P.; Boulland, M. L.; Petit, B.; Arnulf, B.; Gaulard, Ph (2000)Most peripheral T-cell lymphomas (PTCL) express the αβ T-cell receptor (TCR) whereas rare PTCL express the γδ TCR. Most if not all γδ PTCL are extranodal lymphomas and among them, hepatosplenic γδ PTCL constitute a distinct ... -
Expression of p53 protein in T- and natural killer-cell lymphomas is associated with some clinicopathologic entities but rarely related to p53 mutations
Petit, B.; Leroy, K.; Kanavaros, P.; Boulland, M. L.; Druet-Cabanac, M.; Haioun, C.; Bordessoule, D.; Gaulard, P. (2001)To determine if p53 abnormalities could be involved in the pathogenesis of T- or natural killer (NK)-cell lymphomas, we investigated 51 cases of these lymphomas for the expression of p53 and its relationship with p53 gene ... -
Expression of p53, p21/waf1, bcl-2, bax, Rb and Ki67 proteins in Hodgkin's lymphomas
Kanavaros, P.; Stefanaki, K.; Vlachonikolis, J.; Eliopoulos, C.; Kakolyris, S.; Rontogianni, D.; Gorgoulis, V.; Georgoulias, V. (2000)The aim was to investigate the combined immunoexpression of p53, p21, bcl-2, bax, Rb and Ki67 proteins in Hodgkin's lymphomas (HL) and correlate expression patterns with the histotype and the Epstein-Barr Virus (EBV) status. ... -
The expression of the epitope H recognized by the monoclonal antibody H is higher in astrocytomas compared to anaplastic astrocytomas and glioblastomas
Arvanitis, D. L.; Arvanitis, L. D.; Panourias, I. G.; Kitsoulis, P.; Kanavaros, P. (2005)The epitope H contains an O-linked N-acetylglucosamine residue in a specific conformation and/or environment recognized by the monoclonal antibody H (mAbH). mAbH stains two bands with Mr x10-3 of 209 and 62 in lysates of ... -
The expression of the O-linked -N-acetylglucosamine containing epitope H in the gemistocytic, pilocytic, subependymal giant cell, U87 and D54 cell line, astrocytomas
Arvanitis, L.; Koukoulis, G.; Kanavaros, P. (2008) -
The expression of the O-linked N-acetylglucosamine containing epitope H in the gemistocytic, pilocytic and subependymal giant cell astrocytomas
Arvanitis, L. D.; Koukoulis, G. K.; Kanavaros, P. (2009)The epitope H contains an O-linked N-acetylglucosamine residue in a specific conformation and/or environment recognized by the monoclonal antibody H. It has previously been shown that the epitope H is present in several ... -
Extranodal cytotoxic T-cell lymphoma in a patient with X-linked agammaglobulinaemia
Kanavaros, P.; Rontogianni, D.; Hrissovergi, D.; Efthimiadoy, A.; Argyrakos, T.; Mastoris, K.; Stefanaki, K. (2001)This report documents the occurrence of an extranodal cytotoxic peripheral T-cell lymphoma (PTCL) in a patient with X-linked agammaglobulinaemia (XLA). The diagnosis was based on the immunohistochemical detection of T-cell ... -
Immunohistochemical expression of p53, p21/waf1, Rb, p16, cyclin D1, p27, Ki67, cyclin A, cyclin B1, bcl2, bax and bak proteins and apoptotic index in normal thymus
Kanavaros, P.; Stefanaki, K.; Rontogianni, D.; Papalazarou, D.; Sgantzos, M.; Arvanitis, D.; Vamvouka, C.; Gorgoulis, V.; Siatitsas, I.; Agnantis, N. J.; Bai, M. (2001)The immunohistochemical expression of p53, p21, Rb, p16. cyclin Dl, Ki67, cyclin A, cyclin Bl, p27, bcl2, bax, and 6ak proteins and the apoptotic index (At) were investigated in 20 normal thymuses (8 adults, 3 adolescents, ... -
Immunohistochemical expression of the p53, mdm2, p21/Waf-1, Rb, p16, Ki67, cyclin D1, cyclin A and cyclin B1 proteins and apoptotic index in T-cell lymphomas
Kanavaros, P.; Bai, M.; Stefanaki, K.; Poussias, G.; Rontogianni, D.; Zioga, E.; Gorgoulis, V.; Agnantis, N. J. (2001)Fifty-seven cases of T-cell lymphomas (TCL) including 5 lymphoblastic (T-LBL) and 52 peripheral TCL (PTCL) were analyzed by immunohistochemistry for the expression of p53, mdm2, p21, Rb, cyclin D1, cyclin A, cyclin B1, and ... -
Immunohistochemical expression of the p53, p21/Waf-1, Rb, p16 and Ki67 proteins in multiple myeloma
Kanavaros, P.; Stefanaki, K.; Vlachonikolis, J.; Papalazarou, D.; Rontogianni, D.; Arvanitis, D.; Antonakopoulos, G.; Gorgoulis, V.; Bai, M.; Agnantis, N. J. (2000)The aim of this study was to investigate the immunohistochemical expression of the proteins p53, Waf-l/p21, Rb, p16 and Ki67 in 38 cases of multiple myelomas (MM) and 4 cases of solitary extramedullary plasmacytomas in ... -
Immunohistochemicall expression of the p53, p21/Waf-1, Rb, p16 and Ki67 proteins in multiple myeloma
Kanavaros, P.; Stefanaki, K.; Vlachonikolis, J.; Papalazarou, D.; Rontogianni, D.; Arvanitis, D.; Antonakopoulos, G.; Gorgoulis, V.; Bai, M.; Agnantis, N. J. (2000)The aim of this study was to investigate the immunohistochemical expression of the proteins p53, Waf-l/p21, Rb, p16 and Ki67 in 38 cases of multiple myelomas (MM) and 4 cases of solitary extramedullary plasmacytomas in ... -
In vivo cell kinetics in breast carcinogenesis
Bai, M.; Agnantis, N. J.; Kamina, S.; Demou, A.; Zagorianakou, P.; Katsaraki, A.; Kanavaros, P. (2001)Background: Disruption of the balance between apoptosis and proliferation is considered to be an important factor in the development and progression of tumours. In the present study we determined the in vivo cell kinetics ... -
Low levels of p27 in association with deregulated p53-pRb protein status enhance tumor proliferation and chromosomal instability in non-small cell lung carcinomas
Tsoli, E.; Gorgoulis, V. G.; Zacharatos, P.; Kotsinas, A.; Mariatos, G.; Kastrinakis, N. G.; Kokotas, S.; Kanavaros, P.; Asimacopoulos, P.; Bramis, J.; Kletsas, D.; Papavassiliou, A. G.; Kittas, C. (2001)Background: Down-regulation or overexpression of the cyclin-dependent kinase inhibitor p27 have been observed in a range of malignancies, including lung cancer. To further elucidate the role of the molecule in tumor growth ... -
Mitochondria-rich normal, metaplastic, and neoplastic cells show overexpression of the epitope H recognized by the monoclonal antibody H
Arvanitis, D. L.; Arvanitis, L. D.; Panourias, I. G.; Kitsoulis, P.; Kanavaros, P. (2005)The epitope H contains an O-linked N-acetylglucosamine (O-GlcNAc) residue in a specific conformation and/or environment recognized by monoclonal antibody H (mAbH). We have previously shown that the epitope H is present in ... -
Multiplex polymerase chain reaction for the detection of mycobacterial DNA in cases of tuberculosis and sarcoidosis
Ikonomopoulos, J. A.; Gorgoulis, V. G.; Zacharatos, P. V.; Manolis, E. N.; Kanavaros, P.; Rassidakis, A.; Kittas, C. (1999)The aims of the present study were: (1) to design a sensitive and specific polymerase chain reaction-based method that would allow detection of most common human typical and atypical mycobacterial strains and (2) to apply ... -
Primary CD30-positive cutaneous T-cell lymphomas and lymphomatoid papulosis frequently express cytotoxic proteins
Boulland, M. L.; Wechsler, J.; Bagot, M.; Pulford, K.; Kanavaros, P.; Gaulard, P. (2000)Alms: To analyse the relationship between expression of cytotoxic proteins. histopathology and the CD30 status in primary cutaneous T-cell disorders, we investigated the expression of TIA-1, granzyme B and perforin in CD30 ...